• 2 Posts
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Joined 3 years ago
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Cake day: June 6th, 2023

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  • That’s a very important point to consider. Unless you remove the battery, you shouldn’t use it as a server. If you still do, store it in a metal bowl or so and put it somewhere where the heat of the bowl itself cannot start a fire. And make sure that your smoke detectors are still working and not expired. Then, be aware that if the battery explodes, your apartment fills with biting toxic smoke within minutes, and that can happen in the middle of the night. So keep some clothes ready at the door that you can wear when fleeing the apartment.







  • Keep the slop, kill the science. Got it.

    Arguably, approaches to optimisation problems such as AlphaFold are inherently biased and not really suited for real science. While other approaches take longer, their biases can at least be described. It doesn’t help if AlphaFold is super fast, but then you don’t really know if you can trust it’s output. It’s just like ChatGPT which is often correct, but that doesn’t help if you never know when it is correct. However, with protein folding at least you can compare solutions and easily see which is better, because computing the potential energy of an existing solution is relatively simple. The hard part is to find a good solution.

    Anyways, AlphaFold surely has its uses, and surely works well for proteins that fold in some sort of “standard” way, similar to the proteins in the training data set.